Imaging analysis of autophagy between periodontitis and dementia

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K15775
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Nagasaki University
• Principal Investigator: SAITO Toshiyuki 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (10170515)
• Co-Investigator(Kenkyū-buntansha): 林田 秀明 長崎大学, 病院(歯学系), 講師 (20238140) ; 古堅 麗子 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (90253674)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 歯周病 / 認知症 / アディポカイン

Outline of Final Research Achievements

Periodontal disease is local inflammation caused by periodontal pathogens and an association with immuno-response including various cytokines and activation of osteoclast has been clarified. On the other hand, it is reported that periodontal disease is associated with diabetes, arteriosclerosis, and cardiovascular disease, beyond periodontal inflammation and destruction, however, its mechanism has not been clarified well. In this study we hypothesized that periodontal disease has bad effects on glucose and lipid metabolism in nervous cells. From a point of view that periodontal disease and obesity affect each other, in order to clarify this, we examined adhipokine levels in culture system. As a result, stimulation by LPS derived from periodontal pathogens has bad effects on release of adhipokine and cytokine. These phenomena were suggested to be one of mechanisms that periodontal disease influence systemic disease.

Free Research Field

社会歯科学