2016 Fiscal Year Final Research Report
Finding 3D co-localization of genomic elements from HiC data
Project/Area Number |
15K16089
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Life / Health / Medical informatics
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Research Institution | National Institute of Advanced Industrial Science and Technology |
Principal Investigator |
Saito Yutaka 国立研究開発法人産業技術総合研究所, 人工知能研究センター, 研究員 (60721496)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | ゲノム3D構造 / エピゲノム / HiC/3C |
Outline of Final Research Achievements |
We developed Cosearge, a bioinformatics method for finding 3D co-localization of genomic elements from HiC data. We applied Cosearge to HiC data from embryonic stem cells, and detected a number of novel co-localized genes distinct from topologically associated domains proposed in existing studies. In particular, we found that SOX2 and DNA damage response genes are co-localized in embryonic stem cells.
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Free Research Field |
エピゲノム情報解析の新規手法開発
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