2017 Fiscal Year Final Research Report
Elucidation of a mehcanism of Diabete mellitus attributed to ectopic fat and its suppressive effect with food ingredients
| Project/Area Number |
15K16204
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Yamanashi Gakuin University (2017)
University of Yamanashi (2015-2016) |
|---|
Principal Investigator |
Hariya Natsuyo 山梨学院大学, 健康栄養学部, 准教授 (80732784)
|
|---|
| Research Collaborator |
MOCHIZUKI Kazuki
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | インスリン抵抗性 / 食物繊維 / カロテノイド / 異所性脂肪細胞 |
|---|
| Outline of Final Research Achievements |
In this study, we examined the effects of food ingredients and epigenetic factors on pathological condition improvement in each condition of diet induced insulin resistance. It is suggested that β-carotene may lead to exacerbation of the disease state. It turned out that the effect of water - soluble dietary fiber pectin improvement depending on the content of pectin in the diet and the degree of glucose tolerance in type 2 diabetes rats. Inhibition of epigenetic factor BRD4 suppressed the effect of high fructose diet, however pathological condition could be exacerbated by excessive suppression of BRD4.
|
| Free Research Field |
食生活学
|
