2017 Fiscal Year Final Research Report
Regulation mechanism of glucose and lipid metabolism between brain and peripheral organs by neuropeptide GALP
| Project/Area Number |
15K16217
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | University of Human Arts and Sciences |
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Principal Investigator |
Hirako Satoshi 人間総合科学大学, 人間科学部, 講師 (90644261)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | GALP / 抗肥満 / 脂質代謝 / 糖代謝 / マウス |
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| Outline of Final Research Achievements |
Although anti-obesity action has also been reported, details of its mechanism of action are unknown. In this research, we clarified the following. 1. It was suggested that GALP activates the sympathetic nervous system via MC4R. 2. It was revealed that GALP affects not only fatty acid but also bile acid metabolism. 3. The effect of GALP varies depending on the administration time, and it is revealed that lipid metabolism is activated immediately after administration, but glucose metabolism is activated after 16 hours.
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| Free Research Field |
分子栄養学
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