The effects of vitamin E on beige adipocyte differentiation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K16220
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Kanagawa Institute of Technology
• Principal Investigator: Tanaka Rieko 神奈川工科大学, 応用バイオ科学部, 助教 (80579962)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ベージュ脂肪細胞 / ビタミンE / α-トコフェロール / UCP1 / PGC-1α

Outline of Final Research Achievements

Beige and brown adipocytes, which constitute BAT, have many mitochondria containing uncoupling protein 1 (UCP1). UCP1 uncouples the respiratory chain, allowing for fast substrate oxidation, and functions as a radiator for thermogenesis to maintain body temperature. Activation of thermogenic adipocyte has been considered an attractive target for weight loss and treatment of metabolic disease. A PPARγ agonist, rosiglitazone, promotes thermogenic adipocyte differentiation in mouse WAT. It has been reported that α-tocopherol influence PPARγ expression and the target genes expression. In this study, we investigated that the effect of α-tocopherol on beige adipocyte differentiation. The results of our study suggest that α-tocopherol promotes thermogenic adipocyte differentiation. We also suggest that PGC-1α upregulation by α-tocopherol contribute thermogenic adipocyte differentiation.

Free Research Field

食品機能学