Investigation of therapeutic effect of vitamin A on ciliopathy and promotion of its therapeutic effect

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K16222
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Fujita Health University
• Principal Investigator: KUGITA Masanori 藤田保健衛生大学, 疾患モデル教育研究施設, 講師 (50440681)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 繊毛病 / RXR / ビタミンA / ビタミンK

Outline of Final Research Achievements

Nephronophthisis (NPH) and polycystic kidney disease (PKD) stemmed from abnormal function of cilia-related proteins which are coaded by the gene including mutation. Therefore they are called ciliopathy. We found that retinoid X receptor (RXR) could relate to cystogenesis is a character of ciliopathy. A ligand of RXR is 9-cis retinoic acid (9cRA) of vitamin A metabolite. Therefore we investigated that the suppression effect of vitamin A on ciliopathy using cells and model animals for ciliopathy.
We show that the narrow range of optimal concentration of 9cRA which has effect only on ciliopathy, and ingestion of a large amount of vitamin A could worsen pathological condition of ciliopathy.

Free Research Field

分子生物学