2016 Fiscal Year Research-status Report
Investigating the cross-sectional and prospective relationship between dietary acid load and cardiometabolic risk factors including glucose metabolism markers, metabolic syndrome, and type 2 diabetes
| Project/Area Number |
15K16227
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| Research Institution | National Center for Global Health and Medicine |
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Principal Investigator |
アクタル シャミマ 国立研究開発法人国立国際医療研究センター, その他部局等, 研究員 (40623731)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Dietary acid load / PRAL / NEAP / Diet / Type 2 diabetes / Mortality |
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| Outline of Annual Research Achievements |
According to our research plan we already published two papers on dietary acid load score in pair reviewed international journal. We assessed the association between dietary acid load score and risk of type 2 diabetes among Japanese population and we found that high dietary acid load is associated with increased risk of type 2 diabetes among Japanese men. We also examined the association between dietary acid load score and all-cause and cause specific mortality among Japanese. We found that high dietary acid load score was associated with a higher risk of total mortality and mortality from CVD, particularly from heart disease, in Japanese adults. We completed our cross-sectional survey and collected data among approximately 20,000 Japanese employees according to study plan. Using this data, we already completed statistical analysis and draft on the topic “Association of serum and dietary magnesium with glucose metabolism”. This article is also ready to submit. We found that high dietary and serum magnesium is associated with insulin resistance. I also participated in an international and in a national conference and exchange our findings and views with other researchers.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
We already published two papers in pair reviewed international journals based on our existing data. We smoothly completed our follow-up survey and collected data on dietary intake and measured several bio-markers among approximately 20,000 Japanese employees according to study plan. We also completed data cleaning. Soon we will complete new articles and will submit in pair reviewed international journal. We will also present the results of this survey in national and international conference.
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| Strategy for Future Research Activity |
We completed our survey and collected data among approximately 20,000 Japanese employees according to study plan. Using this data, we have planned to analyse the data and writing some more papers on metabolic biomarkers and publish in international pair reviewed journal. I also have planned to participate in international and national conference and exchange our findings and views with other researchers.
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| Causes of Carryover |
We completed our field survey and collected data among nearly 2,000 employees. We collected blood specimens and stored in -80 degree c refrigerator. We have plan to measure some more biomarkers using this stored blood specimen and the incurring amount of money will need for this measurement. As we have data at our hand, we will write paper and publish in international journal and also will join in national and international conference. The incurring amount is needed also to support for this activities.
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| Expenditure Plan for Carryover Budget |
We will measure some more biomarkers. We need to pay publication fee and english editing fee. We will participate in national and in international conferences. We will buy some statistical analysis and nutrition related books.
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[Presentation] Serum fatty acid composition and incidence of type 2 diabetes in Japan2017
Author(s)
1.Akter S, Kurotani K, Sato M, Hayashi T, Kuwahara K, Matsushita Y, Nakagawa T, Konishi M, Honda T, Yamamoto S, Hayashi T, Noda M, Mizoue T
Organizer
The 27th Annual Scientific Meeting of Japan Epidemiologic Association
Place of Presentation
Yamanashi, Japan
Year and Date
2017-01-21 – 2017-01-23
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