2017 Fiscal Year Final Research Report
A study of metabolic dynamics of purine derived from daily diet for prevention of hyperuricemia
| Project/Area Number |
15K16238
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 尿酸値 / プリン体 / 旨み / 食品 / 一斉分析 |
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| Outline of Final Research Achievements |
Purines in foods are often evaluated as the total purine amount (in terms of uric acid), but the purine form exists in various ways, such as nucleic acids, nucleotides, nucleosides, purine bases. These metabolic processes to uric acid, intestinal absorption, and/or more reuse efficiency as energy should be considered also not uniform. Thus, both the amount of total purines in the food and the what types of purine are included are important that should be taken into consideration regarding nutritional therapy for gout or hyperuricemia with particular respect for the restriction of dietary purines. In this study, we determined 19 types of purine(nucleotides ,nucleosides and purine bases) content of daily foods. Furthermore, I aimed to evaluate the effects of purines and other ingredients contained in food on intestinal absorption, and / or extra- and intracellular purine metabolism in cultured cells.
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| Free Research Field |
分析化学
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