Identification of new advanced glycation end-products and food ingredients to diagnose and prevent lifestyle diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K16239
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Kanazawa Medical University
• Principal Investigator: SAKASAI-SAKAI Akiko (坂井亜紀子) 金沢医科大学, 総合医学研究所, 助教 (60570059)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 終末糖化産物 / AGEs / NASH / TAGE

Outline of Final Research Achievements

Life-style disease including NASH has been associated with hyperglycemis state and excessive intake of food derived advanced glycation end-products (AGEs). To diagnose NASH, we had already found that Toxic AGEs (TAGE) to be useful for disease marker, but the TAGE-modified target protein has not be identified yet. In this study, we identified TAGE modified caspase-3 which has a possibility for the diagnosis of NASH. Furthermore, we screened food ingredients that have an effect of suppressing the TAGE modification of caspase-3, and found several substances that can be applied to lifestyle disease prevention factors.

Free Research Field

細胞生物学