Tuberculosis history from the relationship between cattle and human

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K16272
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sociology/History of science and technology
• Research Institution: Nagasaki University
• Principal Investigator: ICHIKAWA Tomoo 長崎大学, 熱帯医学研究所, 助教 (30508875)
• Research Collaborator: YAMAMOTO Taro 長崎大学, 熱帯医学研究所, 教授 ; WADA Takayuki 長崎大学, 熱帯医学研究所, 助教 ; MAEDA Shinji 北海道薬科大学, 薬学部, 教授 ; YANAI Tokuma 岐阜大学, 応用生物科学部, 教授
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 結核 / ウシ結核 / 医学史 / 分子疫学

Outline of Final Research Achievements

This research organized data of historical statistics between 1905 and 1980 in order to analyze the impact of M.bovis to tuberculosis prevalence in Japan. As a result, this data reveals that bovine tuberculosis outbreak occurred in 1920 and 1940 especially around Kinki and Chugoku area. In addition, this research established detection system both of M.tuberculosis and M.bovis from FFPE sample. (①Extract DNA, ② to amplify and the DNA of IS6110 to detect TB, ③ to distinguish TB lineages by Realtime PCR ) The results of detection indicate that all FFPE specimen (299 samples)from TB patients were infected with M.tubelculosis, not M.bovis.

Free Research Field

日本近代医学史