Establishment of safe and effective photodynamic therapy by controlling of type of cell death

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K16322
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka University
• Principal Investigator: Honda Norihiro 大阪大学, 工学研究科, 特任助教(常勤) (60710100)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 光線力学療法 / 一重項酸素 / 計算機シミュレーション / 壊死 / アポトーシス / 一重項酸素生成量子収率

Outline of Final Research Achievements

The determination of appropriate condition for inducing tumor selective and a proper cell death modality in photodynamic therapy (PDT), which is one of the less-invasive tumor treatment method, is very important for enduring safety and effecacy of PDT.The cell death modality depends on the condition of PDT. And, PDT effect depends on the amount of reactive oxygen species, especially singlet oxygen.Then in this study, the relationship between the type of cell death and cumulated generated singlet oxygen in PDT was investigated by computer simulation.

Free Research Field

生体組織光学