In vivo imaging to reveal the mechanisms of cardiovascular diseases induced by mechanical stress

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K16325
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Jichi Medical University
• Principal Investigator: Seo Kinya 自治医科大学, 医学部, 講師 (40747698)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 生体イメージング / 心臓力学

Outline of Final Research Achievements

To elucidate the mechanisms of cardiovascular diseases induced by mechanical stress, we developed in vivo imaging technique to assess morphological changes and calcium dynamics simultaneously in the stressed heart. Combined with in vivo functional analysis and micro-manipulation technique of isolated cardiomyocyte, we revealed that a mechano-sensitive channel plays a crucial role in the contractility augmentation of the heart in response to acute mechanical load. Using in vivo imaging technique, we are currently evaluating the structural deformation and calcium dynamics in response to acute mechanical load to uncover the role of the mechano-sensitive channel.

Free Research Field

生体力学