Development of a construction method for engineered blood vessel networks with efficient transport properties of oxygen and nutrients

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K16330
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Hokkaido University
• Principal Investigator: Furusawa Kazuya 北海道大学, 先端生命科学研究院, 助教 (00510017)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 血管 / コラーゲン / 潅流培養 / 輸送特性 / 組織工学 / 血管内皮細胞

Outline of Final Research Achievements

Introducing the blood vessel that plays a role of transport duct for oxygen and nutrients is a prerequisite for artificially constructing huge organs, such as liver and heart, by using combinations of cultured cells and gels. The blood vessels in our body have excellent transport properties of oxygen and nutrients. The excellent transport properties are attributed to a morphology of blood vessel. In this study, we developed the method for constructing the engineered blood vessel by using the template collagen hydrogel which mimics the morphology of blood vessel in our body. In addition, we developed a device for perfusing a cell culture medium into the engineered blood vessel. We will develop the method for introducing the blood vessels with efficient transport properties of oxygen and nutrients into the huge engineered organs by using the methodologies developed in this study.

Free Research Field

高分子物理学、生体材料学、組織工学、バイオレオロジー