2017 Fiscal Year Final Research Report
Large-scale reorganization of neural circuit after primary motor cortical lesion and recovery
| Project/Area Number |
15K16365
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tsukuba International University |
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Principal Investigator |
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| Research Collaborator |
Yoshida Yuuko
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | リハビリテーション / 脳の可塑性 / 神経回路 / 運動麻痺 / 機能回復 / 霊長類 |
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| Outline of Final Research Achievements |
Previous studies have shown a pivotal role of the ventral premotor cortex (PMv) in an animal model with a focal lesion of the primary motor cortex (M1) and recovery of hand movements. I found potential reorganization of PMv projections to subcortical structures in the chronic stage of M1-lesioned rhesus macaque monkey. The subcortical connections of PMv were compared between two groups of the M1-lesion and motor recovery animals and the intact animals by using biotinylated dextran amine (BDA). Lesion-recovery group showed higher numbers of BDA-labeled axons in red nucleus and deep cerebellar nuclei (particularly, the fastigial nucleus) than in the intact. In the fastigial nucleus, the BDA-labeled terminals were mainly located in the middle to caudal part with no or little expression of aldolase C, supposed to be a somatosensory region. These results suggest that the dynamic increase of PMv projections to cerebellar and red nucleus underlies long-term motor recovery after M1 lesion.
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| Free Research Field |
神経科学
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