Plasticity and evaluation about cerebellar output

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K16422
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Developmental mechanisms and the body works
• Research Institution: Shijonawate Gakuen University
• Principal Investigator: Matsugi Akiyoshi 四條畷学園大学, リハビリテーション学部, 教授 (20624026)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 小脳 / 脊髄反射 / H反射 / 経頭蓋磁気刺激 / 経頭蓋直流電気刺激 / 脊髄小脳変性症

Outline of Final Research Achievements

Spinal reflex associated with control for lower limb muscle is facilitated by cerebellar transcranial magnetic stimulation. This cerebellar spinal facilitation appeared in patent with spinocerebellar ataxia that cerebellar brain inhibition was absent. this facilitation was induced by contralateral cerebellar stimulation. These findings indicate that the origin of this facilitation is not cerebellar cortex associated with cerebellar brain inhibition and the origin can be cerebellar deep nuclei have the functional connectivity to bilateral spinal motoneurons, or brainstem stimulation. On the other hand, the amount of this facilitation was modulated after training for motor learning for control of lower limb, and non-invasive brain stimulation over the cerebellum. This finding indicates that this cerebellar spinal facilitation reflects the plastic change of neural excitability associated with control for lower limb.

Free Research Field

リハビリテーション