Risk of developing diabetic microvascular disease and related factors in individuals with impaired insulin secretion: a large retrospective cohort study

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K16513
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Osaka Prefecture University (2017-2018); Shiga University of Medical Science (2015-2016)
• Principal Investigator: Morimoto Akiko 大阪府立大学, 看護学研究科, 准教授 (90710377)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: インスリン分泌不全 / 食後高血糖 / 糖尿病合併症 / 要因 / コホート研究

Outline of Final Research Achievements

The present study which is a large retrospective cohort study showed that individuals with impaired insulin secretion have a high risk of developing postprandial hyperglycemia, after adjusting for confounding factors such as age, sex, family history of diabetes, lifestyle factors, waist circumference, blood pressure, and blood glucose level at baseline. Additionally, the present study showed that smoking and metabolic syndrome affect postprandial hyperglycemia onset in those with impaired insulin secretion, and that blood pressure affect diabetic nephropathy onset in those with impaired insulin secretion.

Free Research Field

保健学

Academic Significance and Societal Importance of the Research Achievements

日本を含む東アジアの糖尿病人口は爆発的に増加しており、日本人(東アジア人)の特徴に基づいた糖尿病発症予防、糖尿病合併症予防が重要である。日本人(東アジア人)の特徴としてインスリン分泌が不良な者が多いことに着眼し、インスリン分泌不全者における食後高血糖発症に影響する要因や、糖尿病腎症発症に影響する要因を明らかにしたことは、日本(東アジア)における糖尿病発症予防、糖尿病合併症予防に有用である。