Molecular mechanism of muscle hypertrophy by osteoblasts

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K16517
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Ehime University
• Principal Investigator: Sakakibara Iori 愛媛大学, プロテオサイエンスセンター, 助教 (50734662)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 骨格筋 / 骨 / 共培養

Outline of Final Research Achievements

The change of muscle mass and bone mass are well synchronized through aging and by environmental stimuli, which suggested the existence of crosstalk between skeletal muscles and bones. The signals from skeletal muscles to bones are well analyzed compared with the signal from bones to muscles. The purpose of this study is to clarify the signal from bones to muscles. Direct co-culture of myoblasts and osteoblasts promoted myoblast differentiation into myotube accompanied with spontaneous myotube contraction. This study proved the positive signal from osteoblast for myoblast differentiation.

Free Research Field

骨格筋