Mechanism of anti-inflammatory action of molecular hydrogen from epigenetic control

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K16525
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: Waseda University (2017); Nippon Medical School (2015-2016)
• Principal Investigator: lee hyunjin 早稲田大学, ナノ・ライフ創新研究機構, その他(招聘研究員) (80734441)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 活性酸素種 / 水素 / エピジェネティクス / 抗酸化物質

Outline of Final Research Achievements

The purpose of this study is to elucidate the anti oxidant efffect mechanism of hydrogen through confirming the effect of molecular hydrogen on epigenetic abnormality in lifestyle - related diseases.
Cells were used to ascertain the effect of molecular hydrogen under conditions causing epigenetic abnormality. As a result, it was confirmed that molecular hydrogen changes epigenetics including activation of HDAC. However, it was not possible to examine the effect of moluecular hydrogen by using a high-fat diet intake animal model, and the existence of epigenetic change in an animal model has time to establish a methodology, and at the stage of comparing and examining It did not arrive.

Free Research Field

応用健康科学