2016 Fiscal Year Final Research Report
Role of orexin-A for cerebral stroke through the communication system between brain and peripheral tissues
| Project/Area Number |
15K16533
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 脳虚血 / 耐糖能異常 / orexin-A / 迷走神経 / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
We have reported that hypothalamic orexin-A-induced activation of vagus nerve recovered the development of post-ischemic glucose intolerance and mediates a neuroprotective effect. The aim of this study was to determine the involvement of orexin-A and vagus nerve on the changes in cerebral ischemia-induced inflammatory signaling. Male ddY mice were subjected to 2 hr of middle cerebral artery occlusion (MCAO). Intrahypothalamic OXA (5 pmol/mouse) administration significantly suppressed the development of post-ischemic glucose intolerance on day 1 after MCAO. In the liver, MCAO-induced increase in TNF-α, IL-1β, c-Jun N-terminal kinase and serine-phosphorylated insulin receptor substrate on day 1 was recovered to control levels by OXA, and which was reversed by hepatic vagotomy. These results suggest that hypothalamic orexin-A-induced activation of vagus nerve may play an important role in the regulation of post-ischemic changes in hepatic inflammatory signaling.
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| Free Research Field |
中枢神経薬理
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