Scientific elucidation of oxidative stress involvement in glaucoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K16538
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: UMENO AYA 国立研究開発法人産業技術総合研究所, 生命工学領域, 産総研特別研究員 (20749098)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 一重項酸素 / 緑内障 / ヒドロキシリノール酸 / 10-(Z,E)-HODE / 12-(Z,E)-HODE / 酸化ストレス

Outline of Final Research Achievements

Glaucoma (PG) is characterized as progressive glaucomatous optic neuropathy leading to visual field loss. It is a cause of irreversible blindness worldwide. We proposed totally assessed hydroxylinoleates (HODEs) from biological samples as biomarkers for investigations of pathogenesis, disease progression, and prognosis. HODEs consist of six isomers that are yielded by a radical, singlet oxygen and enzymes oxidation. In the present study, we investigated the involvement of oxidative stress in this disease by using our own proposed oxidative stress marker HODEs quantitatively. PG patients (n = 198) were recruited depending on intraocular pressure (IOP). In the PG group, serum levels of HODEs demonstrated higher levels than those in the cataract (CT) group. Furthermore, HODEs levels increased with the increase in IOP, suggesting that the systemic oxidation is involved in PG at least partially.

Free Research Field

酸化ストレス