Synthetic study on fluorecent probe of antifouling natural products toward elucidation of molecular mechanism

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K16551
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomolecular chemistry
• Research Institution: Hokkaido University
• Principal Investigator: Umezawa Taiki 北海道大学, 地球環境科学研究院, 准教授 (20503618)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 天然有機化合物 / 付着阻害 / 全合成

Outline of Final Research Achievements

This study aims syntheses of fluorescent probe of antifouling natural products. As lead compounds for antifouling materials, omaezallene (brominated compound) and dolastatin 16 (cyclic peptide) are selected becuase these exhibit strong antifouling activity along with very low toxicity toward cypris larvae of Amphibalanus amphitrite. Elucidation of molecular mechanism of antifouling activity expects the development of ideal antifouling material.
Syntheses of omaezallene derivatives was achieved, which includes fluorescent derivative. A new synthetic pathway to dolastatin 16 and the antifouling activity of synthetic sample were revealed. Functionalization method toward fluorescent compound was also developed.

Free Research Field

有機合成化学