Elucidation of the selective cytotoxicity of tomuruline, a novel thiazole-containing polyketide, under nutrient-starvation conditions

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K16555
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biomolecular chemistry
• Research Institution: Kogakuin University
• Principal Investigator: Ohno Osamu 工学院大学, 先進工学部, 准教授 (20436992)
• Research Collaborator: SUENAGA Kiyotake ; MATSUNO Kenji
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: トムルリン / 栄養飢餓 / 呼吸鎖 / シアノバクテリア / カルキピロン / リプログラミング / 小胞体ストレス

Outline of Final Research Achievements

The biological activity of the novel thiazole-containing polyketide tomuruline was elucidated to be the selective cytotoxicity toward cancer cells under glucose-restricted conditions. In addition, it was proved that tomuruline exerted cytotoxicity based on its selective inhibitory activity against the mitochondrial complex I activity. Next, we searched for compounds that showed the selective cytotoxicity toward cancer cells under nutrient-starvation conditions, and isolated kalkipyrone from marine cyanobacterium collected in Okinawa. Kalkipyrone was found to show the same biological activity with that of tomuruline. Meanwhile, we isolated new inhibitors of kynurenine-production and ER stress using the screening systems related to the nutrient starvation in cancers.

Free Research Field

生物分子科学