Development of novel molecular tool for controlling sleep/wake cycle and feeding behavior

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K16557
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Chemical biology
• Research Institution: University of Tsukuba
• Principal Investigator: SAITOH Tsuyoshi 筑波大学, 国際統合睡眠医科学研究機構, 助教 (80609933)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: オレキシン / 睡眠覚醒 / 光ケージド化合物 / 作動薬

Outline of Final Research Achievements

Purpose of this project is to develop novel molecular tool for controlling sleep/wake cycle and feeding behavior. Especially, we employed photo-caging technique to control the orexin agonist activity with light. Our main discoveries are the followings; 1) We discovered novel potent and selective orexin 2 receptor agonist YNT-185 and explored the target brain region of this molecule. 2) We designed and synthesized photo-caged orexin receptor agonist based on the structure-activity relationship study of orexin receptor agonist. 3) The caged molecule was investigated the photoresponcibility and electrophisiological responce.

Free Research Field

ケミカルバイオロジー