2016 Fiscal Year Annual Research Report
Development of a novel gel-display drug screening technique
| Project/Area Number |
15K16558
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| Research Institution | The University of Tokyo |
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Principal Investigator |
パシオラ トビー 東京大学, 大学院理学系研究科(理学部), 助教授 (60750239)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | chemical biology / peptide / antibiotic |
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| Outline of Annual Research Achievements |
The goal of this work was to identify antibiotics for the treatment of drug resistant bacterial infections, through the use of a novel screening methodology. Although the screening process did not run completely as planned, we were nevertheless able to identify 16 candidate inhibitors of bacterial metallo-beta-lactamases - clinically relevant drug-resistance enzymes for which there are no known potent inhibitors. Four of these appear to be highly potent (IC50 values in the low nanomolar range) and work against a diverse range of related bacterial enzymes. Further characterisation of these compounds is ongoing, with the aim of developing one or more of these compounds into therapeutics.
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Research Products
(2 results)
