2016 Fiscal Year Final Research Report
Development of a novel gel-display drug screening technique
| Project/Area Number |
15K16558
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Passioura Toby 東京大学, 大学院理学系研究科(理学部), 特任助教 (60750239)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | Chemical Biology / Peptide / Antibiotic |
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| Outline of Final Research Achievements |
The goal of this work was to identify new antibiotics for the treatment of drug resistant bacterial infections. We identified 16 candidate inhibitors of bacterial antibiotic-resistance enzymes. Four of which are highly potent and exhibited activity against enzymes from multiple different drug-resistant strains of bacteria. These compounds may be used to develop drugs for the treatment of antibiotic resistant bacterial infections.
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| Free Research Field |
Chemical Biology
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