Development of antibody-drug conjugate for controlling drug efficacy by photo-irradiation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K16561
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Chemical biology
• Research Institution: Japan Advanced Institute of Science and Technology
• Principal Investigator: WATANABE TAKAYOSHI 北陸先端科学技術大学院大学, 先端科学技術研究科, 助教 (70554020)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: タンパク質 / 抗体 / 抗体薬物複合体 / 非天然アミノ酸 / ケージド化合物

Outline of Final Research Achievements

In this study, a novel method for modifying functional molecules specific to the N-terminus of proteins while maintaining the activity of proteins without using non-natural amino acids was developed. By using this N-terminal-specific modification method, development of a novel method for synthesizing an antibody-drug conjugate in which an anticancer drug has been modified against IgG antibody used in clinical practice as antibody drugs was achieved. Furthermore, through these research processes, the findings on rational design guidelines for synthesizing caged antibody-drug conjugate could be obtained.

Free Research Field

化学生物学