Frontal-parietal network mechanism of the bodily awareness

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K17334
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental psychology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: HIROAKI Ishida 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主任研究員 (70728162)
• Research Collaborator: GRANDI Laura Clara University of Parma, Department of Neuroscience, Unit of Physiology, 大学院生
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 感覚運動統合 / 島皮質 / 運動前野 / 頭頂葉 / 扁桃体 / 大脳基底核 / 狂犬病ウイルス / 単一ニューロン活動

Outline of Final Research Achievements

The aims of the present project were to investigate; 1) the neural activity within the premotor-insula-parietal regions in the macaque monkey; 2) the neural network between the ventral premotor (PMv) areas and the basal ganglia (BG) or the amygdala (Amyg). To this purpose monkeys were tested in sensory (visual, somatosensory)-motor tasks. Further, we employed retrograde transneuronal labeling with rabies virus to identify the origins of multisynaptic projections from the BG/Amyg to the PMv in macaque monkeys. As so for, the results showed that neurons in the insular cortex were active during hand-mouth movement and during passive tactile stimulation. Further, PMv receives inputs from motor and limbic territories of BG/Amyg. Our results suggested that the frontal-parietal network is involved in both motor and limbic cognitions.

Free Research Field

システム神経科学