2016 Fiscal Year Final Research Report
Development of Aromatic C-H Functionalization Triggered by Cation-pi Interaction
| Project/Area Number |
15K17854
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | C-H官能基化 / 遷移金属触媒 |
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| Outline of Final Research Achievements |
Selective C-H functionalization of simple arenes with no directing group still remains challenges. Catalytic system utilizing substrate-ligand interaction is a powerful approach to exhibit excellent reactivity and selectivity. In the previous reports, substrate-ligand interactions are limited to hydrogen bond, pi-stacking or acid-base interaction. Therefore substrates require some functional groups. For C-H functionalization of simple arene, I herein examined cation-pi interaction between arene substrate and ligand.
I succeeded in preparing a variety of ligands having diverse linkers. Catalytic activity of these ligands was next examined in several C-H functionalization of benzene, while reactions hardly proceeded in all cases. NMR study indicated that activation ability of the ligands was little for accelerating the C-H activation process. However, during these reaction screening, novel C-H functionalization of amine was discovered.
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| Free Research Field |
有機合成化学
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