Development of Phosphine-Borane Ligand for Unactivated Carbon-Oxygen Bond Cleavage

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K17858
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry
• Research Institution: Nagasaki University
• Principal Investigator: ONODERA Gen 長崎大学, 工学研究科, 准教授 (90433698)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ホスフィン－ボラン / パラジウム / アリルアルコール / アミノ化反応 / アルキル化反応 / ベンジルアルコール

Outline of Final Research Achievements

The aim of this study was developing the transition-metal-catalyst system to activate the C-O bond by using phosphine-borane ligand bearing Lewis acidic borane moiety. The various kinds of phosphine-borane compounds were prepared. Among these phosphine-borane compounds, the best ligand for the palladium-catalyzed direct allylic amination of allylic alcohol was found. As an application, the efficient palladium/phosphine-borane catalyst system for the allylic alkylation of allylic alcohol with active methylene compound was developed.

Free Research Field

合成化学