2017 Fiscal Year Final Research Report
Development of trifluoromethylation reaction by using a novel chiral hypervalent iodine catalyst
| Project/Area Number |
15K17860
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Kawamura Shintaro 国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 (60732956)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | トリフルオロメチル化 / 過酸化トリフルオロアセチル |
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| Outline of Final Research Achievements |
Trifluoromethylated compounds as drugs and medicines have attracted much attention due to improved pharmaceutical activity. Based on my previous work, I designed a stereoselective trifluoromethylation of alkenes by using hypervalent iodine catalyst. A combination of oxidants and CF3 sources is important to achieve the reaction and was examined carefully. As the result, a fluoro diacyl peroxide was found to be available for the each steps in the catalytic cycle of the desired reaction.
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| Free Research Field |
有機合成化学
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