2016 Fiscal Year Final Research Report
Design of Glycopolymers for Creating Glycoprotein Mimics
| Project/Area Number |
15K17870
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer chemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 糖鎖高分子 / オリゴ糖 / RAFT重合 / 糖クラスター効果 / レクチン / コアシェル構造 / 温度応答性 / 保護基フリー |
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| Outline of Final Research Achievements |
We focused on glycopolymers which had pendant saccharides on a synthetic polymer backbone. Glycopolymers were designed and synthesized with the idea based on a protein structure. Acrylamide derivative glycomonomers were synthesized from free saccharides via 2 steps, direct anomeric azidation and copper-catalyzed azide-alkyne cycloaddition. The resulting glycomonomers were subjected to RAFT copolymerization with acrylamide and other monomer substrates. The glycopolymers were able to be suspended into water depend on the ratio of monomer units and formed core-shell aggregation. On binding assay of the glycopolymers with lectins, high binding affinity were observed.
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| Free Research Field |
高分子化学
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