Functional Vaccine Carriers by using Chemically Modified Fullerene Nanostructures

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K17890
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: National Institute for Materials Science
• Principal Investigator: MINAMI KOSUKE 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, NIMSポスドク研究員 (10747463)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ドラッグデリバリーシステム / フラーレン / ナノバイオ

Outline of Final Research Achievements

Vaccine has an emerging field for preventing serious diseases as well as for preventing and curing cancers. However, conventional vaccines have limitations for further applications. It is required that the carrier vehicles for effectively delivery of vaccines. We focused on the chemically functionalized fullerene nanostructures because of their properties as anti-oxidant and carrier for DDS. We synthesized the molecular libraries of chemically functionalized fullerene derivatives and precisely tuned their nanostructures. We used the liquid-liquid interfacial precipitation method for controlling fullerene nanostrucutes. We revealed that some of the fullerene library have applied for cellular scaffolds and showed no cytotoxicity. We are further investigating their properties to apply for vaccine carrier vehicles.

Free Research Field

有機合成化学