Tailor-made drug carrier: Design and application of aggregates based on the physicochemical properties

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18279
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biofunction/Bioprocess
• Research Institution: Nara National College of Technology
• Principal Investigator: Hayashi Keita 奈良工業高等専門学校, 物質化学工学科, 講師 (10710783)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 自己集合体 / 薬剤カプセル / ドラッグ・デリバリー・システム

Outline of Final Research Achievements

It has been investigated about the relationship between physicochemical properties of self-assembled aggregates and their functions as drug carriers. Span and Tween series surfactants were employed to prepare various kinds of self-assembled aggregates. Spherical micelle was prepared by Tween surfactants. Mixing with Span surfactants changed formation from a micelle to a vesicle. These aggregates were characterized by DSC, 1H NMR and Laurdan. Micelles were dynamic, while vesicles were rigid state. Therefore, hydrophobic molecules easily entered hydrophobic region of micelles as compared with vesicles. This result shows the relationship between physicochemical properties of self-assembled aggregates and their functions as drug carriers, and it is important to understand systematically about the formation-dependent physicochemical properties of aggregates for “tailor-made drug carrier”.

Free Research Field

生物機能・バイオプロセス