2016 Fiscal Year Final Research Report
Change of gamma-aminobutyric acid receptors amount during hippocampal long-term potentiation of inhibition
| Project/Area Number |
15K18338
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 神経科学 / 分子生物学 / ライブイメージング / シナプス可塑性 / 抑制性長期増強 / 抑制性長期抑圧 / GABA受容体 / 全反射顕微鏡 |
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| Outline of Final Research Achievements |
The efficacy of synaptic transmission changes depending on the pattern of neuronal activity. This synaptic plasticity has been regarded as a cellular basis of learning and memory. In this study, we have suggested that the amounts of gamma-aminobutyric acid receptor on postsynaptic membrane and gephyrin are changed during hippocampal inhibitory synaptic plasticity by experiments using total internal reflection fluorescence microscopy. In addition, we have succeeded in visualization of transient increase of glutamate receptors’ endocytosis during hippocampal long-term depression
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| Free Research Field |
神経細胞生物学
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