Rational design of ultrafast multicolor Ca2+ indicator

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18372
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: The University of Tokyo
• Principal Investigator: Inoue Masatoshi 東京大学, 大学院医学系研究科(医学部), 客員研究員 (60750065)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: カルシウムセンサー

Outline of Final Research Achievements

In order to elucidate how information is encoded and processed at the circuit, single neuron, and subcellular resolution in vivo, it is necessary to measure the activity of a specific neuronal cell type in a living animal. However, it has been difficult to resolve high frequency spiking of neurons, which is essential for deciphering the information code represented by individual neurons. Furthermore, there have been no methods for measuring the activities of more than 3 cell types simultaneously in vivo. Therefore, to overcome these problems, I succeeded in developing a series of neural activity sensors of ultrafast and multiple color palettes in vivo.

Free Research Field

神経生化学