2016 Fiscal Year Final Research Report
The screening for the genes to function during egg maturation
| Project/Area Number |
15K18387
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka University |
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Principal Investigator |
Mori Masashi 大阪大学, 微生物病研究所, 助教 (00747941)
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| Research Collaborator |
Ikawa Masahito 大阪大学, 微生物病研究所伊川研究室, 教授
Abbasi Ferheen 大阪大学, 微生物病研究所伊川研究室, 学生
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 生殖 / 卵母細胞 |
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| Outline of Final Research Achievements |
Since aged oocytes often have abnormality in its maturation, we aimed to understand oocyte maturation. At the beginning, we planed to screen the genes to fucntion during oocyte maturation by knock down with siRNA. However a similar paper was published by other group, and we changed our strategy to screen by knock out mice. We produced KO mice for 9 genes, and found that 1 KO line can be infertile.
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| Free Research Field |
生殖
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