2017 Fiscal Year Final Research Report
Molecular characterization of the leukemic stem cells maintaining GATA1-related DS-AMKL
| Project/Area Number |
15K18395
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 白血病幹細胞 / DS-AMKL |
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| Outline of Final Research Achievements |
Elucidating the function of leukemic stem cell, that generates leukemic blasts and retains self-renewal potency, is required for characterization of leukemia and improving efficiency of chemo-therapy. The aim of this study is identification and characterization of the leukemic stem cell sustaining Down-syndrome associated acute megakaryoblastic leukemia (DS-AMKL). Human DS-AMKL- or hematopoietic stem cell-xenograft mice enabled to provide and analyze human leukemic cells and healthy hematopoietic stem cells stably. Utilizing this system, CD34 positive and Hoechst high-stained fraction was identified as a candidate fraction residing leukemic stem cell in this DS-AMKL. This information provides useful guideline to isolate the fraction with high concentration of leukemic stem cells.
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| Free Research Field |
分子血液学
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