2016 Fiscal Year Final Research Report
Analysis of the function of NFYA in cancer heterogeneity formation
| Project/Area Number |
15K18407
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kanazawa University (2016)
Kyoto University (2015) |
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Principal Investigator |
OKADA Nobuhiro 金沢大学, がん進展制御研究所, 特任助教 (60742377)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 腫瘍内不均一性 / 上皮間葉転換（EMT） / 乳癌 |
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| Outline of Final Research Achievements |
Breast cancer is classified into five subtypes by gene expression profile. In case of breast cancers, cancer heterogeneity that some different subtypes cooperate to enhance malignant progression is proposed. It is suggested that cancer heterogeneity makes it difficult to develop cancer therapy. We elucidated that NFYA plays two different roles by switching the expression of splicing variants, thereby NFYA induces the switching of breast cancer subtypes and enhances the acquisition of cancer heterogeneity.
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| Free Research Field |
腫瘍生物学
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