2016 Fiscal Year Final Research Report
Novel histone chaperone GRWD1 inhibits p53 and promotes tumorigenesis
| Project/Area Number |
15K18412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | GRWD1 / p53 / 発がん / MDM2 / RPL11 |
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| Outline of Final Research Achievements |
GRWD1 is a novel histone chaperone that promotes MCM loading and may integrate regulations of cell cycle progression. We identified ribosomal protein RPL11 as a putative GRWD1 binding factor. Under nucleolar stress induced by treatment with low levels of actinomycin D or nutrient deprivation, RPL11 binds to and inhibits the MDM2 ubiquitin ligase, thereby promoting p53 stability. We found that GRWD1 inhibits RPL11-MDM2 interaction, abrogates RPL11-mediated p53 stabilization, and promotes tumorigenesis.
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| Free Research Field |
分子生物学
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