2016 Fiscal Year Final Research Report
Identification of the biomarker in cerebrospinal fluid of glioblastoma by innovative proteomics
| Project/Area Number |
15K18427
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor diagnostics
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| Research Institution | Kurume University (2016)
Kanazawa University (2015) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAKADA Mitsutoshi 金沢大学, 医学系, 教授 (20334774)
OTSUKI Sumio 熊本大学, 大学院生命科学研究部, 教授 (60323036)
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| Research Collaborator |
DONG Yu
KITABAYASHI Tomohiro
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | バイオマーカー / プロテオミクス / 膠芽腫 |
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| Outline of Final Research Achievements |
The purpose of this study is establishment of the biomarker that can identify glioblastoma, one of the most malignant brain tumor, early in the disease progression and recurrent stage. We analyzed cerebrospinal fluid derived from patients with the innovative proteomics and identified several biomarker candidate proteins. One of the candidates was involved in tumor angiogenesis and found that it is highly expressed in glioblastoma. This protein has never been reported as a biomarker of glioblastoma. In addition, it was also revealed that this candidate protein was highly expressed specifically in glioblastoma.
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| Free Research Field |
脳腫瘍
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