Development of novel therapeutic agents for malignant peripheral nerve sheath tumor

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18436
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor therapeutics
• Research Institution: Tohoku University
• Principal Investigator: Saijo Ken 東北大学, 大学病院, 助教 (70636729)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 悪性末梢神経鞘腫 / 軟部肉腫 / HDAC / PI3K

Outline of Final Research Achievements

Malignant peripheral nerve sheath tumor (MPNST) is a histologic subtype of soft tissue sarcoma. Patients with advanced soft tissue sarcoma including MPNST have poor prognosis and no effective therapeutic drugs, so that development of novel therapeutic drugs is awaited. We have found that depsipeptide analogs inhibit cancer cell proliferation with a mechanism of dual inhibition of HDAC and PI3K, both of which are regarded as molecular targets for soft tissue sarcoma therapy. In this study, the effects of depsipeptide analogs were evaluated using MPNST cell lines and a fibrosarcoma cell line. Because the proliferation rate of MPNST cells was slow and it was difficult to establish an experimental system by a mouse model, experiments were carried out using a fibrosarcoma cell line. We showed antitumor effect and the mechanism of action of HDAC/PI3K dual inhibition of the depsipeptide analog in fibrosarcoma tumor tissue.

Free Research Field

臨床腫瘍学