2016 Fiscal Year Final Research Report
exploring direct target genes of HDAC inhibitor for epigenomic evidenced based medicine
| Project/Area Number |
15K18441
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor therapeutics
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
Tanimoto Kousuke 東京医科歯科大学, 難治疾患研究所, 助教 (60611613)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | ヒストン脱アセチル化酵素阻害剤 / ヒストンアセチル化 |
|---|
| Outline of Final Research Achievements |
H3 acetylation profiles of Jurkat cell line with and without HDAC (histone deacetylase) inhibitor SAHA (Vorinostat) treatment were analyzed by ChIP-seq. Integrated analysis of H3 acetylation profile and gene expression profile revealed that only 7 % genes were acetylated among up-regulated genes by SAHA treatment. This result suggested that exploring direct target of HDAC inhibitor require not only gene expression analysis but also histone acetylation analysis.
|
| Free Research Field |
ゲノム科学
|
