2017 Fiscal Year Final Research Report
Development of new treatments for neuroblastoma based on the synthetic lethality
| Project/Area Number |
15K18442
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor therapeutics
|
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| Research Institution | Nagoya University |
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Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 合成致死 / 神経芽腫 |
|---|
| Outline of Final Research Achievements |
MYCN gene amplification clearly correlates with poor prognosis in patients with pediatric cancer, neuroblastoma. Recently, synthetic lethal (SL) approaches are emerging as a promising strategy for MYCN-amplified neuroblastoma therapy. Therefore, we performed a genome-wide shRNA library screening to identify new candidate genes. Based on our experimental validations using siRNA and chemical inhibitors, some enzymes involved in nucleic acid metabolism were proposed to be new SL targets. Our result suggest that repositioning of existing agents would be worth considering as a new therapeutic strategy. Moreover, finding new chemical inhibitors of new SL targets is important for therapeutic development.
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| Free Research Field |
腫瘍治療学
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