Reactivation of tumor-associated immune cells by gene manipulated iPSCs

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K18445
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor therapeutics
• Research Institution: Kyoto University
• Principal Investigator: Iriguchi Shoichi 京都大学, iPS細胞研究所, 特定研究員 (50737442)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: iPS細胞 / がん免疫療法

Outline of Final Research Achievements

Cancer cells cannot maintain itself without the presence of the stromal cells including fibroblasts and the cells of the immune system. Recent clinical studies have demonstrated the possibility of manipulating immune cells in the tumor for the treatment of otherwise refractory cancers. In the present study, we evaluated the potential of T cells differentiated from a T cell with a tumor-specific helper activity for the reactivation of immune cells in the tumor microenvironment. The results suggest the feasibility of inducing a strong tumor-specific immunity by using iPS technology.

Free Research Field

幹細胞生物学