Deciphering responses to nutrient balances by comparative multi-omics approaches

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K18455
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Genome biology
• Research Institution: Kyoto University
• Principal Investigator: Hattori Yukako 京都大学, 生命科学研究科, 助教 (50646768)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 栄養バランス / 適応 / 比較マルチオミクス / ショウジョウバエ近縁種

Outline of Final Research Achievements

In nature, dietary conditions are subject to changeable environments. To address how developing animals cope with such nutritional changes, we are comparing dietary responses of Drosophila species: two generalists that breed in a wide variety of fruits, and three specialists that feed on specific fruits or flowers. The generalist larvae developed on three diets with different nutrient balances, whereas the specialist larvae reduced their developmental rates on carbohydrate-rich diets. We found that a large number of metabolites became more abundant in a specialist that fed on the carbohydrate-rich diet. We are focusing on one of the sugar-sensing mechanisms in a generalist D. melanogaster, TGF-beta/Activin signaling, and examining their roles in the adaptation of the generalists.

Free Research Field

発生生物学