2016 Fiscal Year Final Research Report
The effect of colonization of human saliva bacteria in the gut
| Project/Area Number |
15K18461
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Medical genome science
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
Wataru Suda 慶應義塾大学, 医学部(信濃町), 講師 (20590847)
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | ヒト常在細菌 / 唾液細菌叢 |
|---|
| Outline of Final Research Achievements |
In this study, we identified the human salivary bacterial species which have the ability to colonize gut, and evaluated their roles against the host cell immunology. To this aim, the gnotobiotic mice which were transplanted the human salivary microbiota from healthy adults and IBD patients were made. The result of flow cytometry of TH1 and Th17 cell indicated that the frequency of TH1 and TH17 cells increased in the several gnotobiotic mice compared with GF mice. We isolated several bacterial strains relating to the gut inflammation from these gnotobiotic feces.
|
| Free Research Field |
微生物学
|
