2016 Fiscal Year Final Research Report
Global analysis of core histones required for homologous recombination repair
| Project/Area Number |
15K18481
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Molecular biology
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| Research Institution | Tohoku Medical and Pharmaceutical University |
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Principal Investigator |
NAKABAYASHI Yu 東北医科薬科大学, 薬学部, 助手 (10710361)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | ヒストン / クロマチン / DNA修復 |
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| Outline of Final Research Achievements |
Damaged DNA is repaired on chromatin structure in a cell. However, it is remain unclear how core histones (H2A, H2B, H3, H4), major components of chromatin, regulate DNA repair pathway choice. In this study, I found that 1) an H2A residue on nucleosome acidic patch is required for efficient DNA resection, 2) H3 and H4 residues interact with each other have an important function on DNA repair pathway choice to promote homologous recombination repair. These results show that not only histone modifications but also unmodifiable histone residues play critical roles on DNA repair.
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| Free Research Field |
DNA修復
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