2016 Fiscal Year Final Research Report
Structural study of regulation of ryanodine receptor
| Project/Area Number |
15K18484
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Structural biochemistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 構造解析 / カルシウム |
|---|
| Outline of Final Research Achievements |
Structural studies of huge calcium channel, Ryanodine receptors (RyR) and its regulatory proteins Calsequestrin (CSQ) and Junctin (JCT) were performed. CSQ has been found to assume an extended conformation or a compact conformation, depending on the calcium concentration. CSQ and JCT formed heterogeneous complexes likely through electrostatic interactions.
|
| Free Research Field |
構造生物学
|
