2016 Fiscal Year Final Research Report
Structural Study of Influenza Virral NP and importin5 of Host Cell Factor.
Project/Area Number |
15K18499
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Structural biochemistry
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Research Institution | Kanagawa Academy of Science and Technology |
Principal Investigator |
Yoshida Hisashi 公益財団法人神奈川科学技術アカデミー, 革新的インフルエンザウイルス創薬プロジェクト, 研究員 (90724774)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | インフルエンザウイルス / X線結晶構造解析 / 核輸送 / 宿主因子 |
Outline of Final Research Achievements |
In recent years, avian influenza infections in humans have been a large problem in the world. Influenza virus is able to grow effectively in the infectious cell using the host cell machinery. The three subunits of influenza RNA polymerase interact with the host cell importin family to move into the nucleus, then replication and transcription of viral gene is performed by RNA polymerase. NP which forms ribonucleoprotein cmplex with the viral RNA and RNA polymerase, is imported into the nucleus by the imporinα5. Although the nuclear localization of these proteins has been found to affect the growth efficiency of the virus, the details of molecular mechanisms such as the influence of the mutation is unclear. Crystallographic study was performed to resolve the interaction mechanism between NP and importinα5
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Free Research Field |
構造生物学
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