2016 Fiscal Year Final Research Report
Transport carrier biogenesis at the Golgi complex and its role in regulating cellular functions
| Project/Area Number |
15K18507
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
Wakana Yuichi 東京薬科大学, 生命科学部, 助教 (90635187)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | オルガネラ膜接触 / 小胞体 / ゴルジ体 / 輸送小胞 |
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| Outline of Final Research Achievements |
In this study, we focused on CARTS, a new class of transport carriers that mediate protein secretion, aiming to elucidate (1) molecular mechanisms by which ER-Golgi contacts regulate CARTS biogenesis and (2) physiological roles of CARTS in mitotic cells. For the first aim, we succeeded in the identification of a novel component of ER-Golgi contact sites, which is involved in protein secretion. Our data also suggest the involvement of the contacts in Ca2+-dependent cargo sorting. Although we could not achieve the second aim, our data imply a novel function of components of the contact sites.
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| Free Research Field |
細胞生物学
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